Epilepsy Talk

For Refractory Epilepsy — Two AEDs and You’re Home Free!

A recent University of Washington report, published in the journal of the American Academy of Neurology, found a combination of two common drugs, lamotrigine and valproate, is more effective in treating refractory epilepsy than other anti-epileptic regimens.

In a large-scale retrospective study of patients with very difficult-to-control epilepsy, researchers discovered that out of the 32 drug combinations studied, only the lamotrigine/valproate treatment regimen significantly decreased seizure frequency in this group. This specific combination reduced seizure frequency by about half, on average, compared to other regimens.