The controversy about generic drugs continues…
The US Food and Drug Administration (FDA) defines a generic drug as being “identical, or bioequivalent, to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use.”
The FDA states that generic epilepsy drugs are just as beneficial as brand name drugs and there is no medical concern when substituting a generic medication for a brand name.
However, many doctors who specialize in treating patients with epilepsy have noted differences in those treated with generic medications compared to those treated with brand name ones.
To read more go to: http://www.rscdiagnosticservices.com/blog/generic-drugs-vs-brand-name-anti-seizure-medications
To subscribe to Epilepsy Talk and get the latest articles, simply go to the box on the bottom of the right column, enter your email address and click on “Follow.”
Not only can there be a difference between generic and brand name but also between different manufacturers of generics there can be a huge difference..
LikeLiked by 2 people
Comment by Zolt — July 24, 2020 @ 1:00 PM
Also, there can be a difference between different manufacturers of “brand-name drugs”.
According to an Epilepsy Foundation report, more than 1000 consumers surveyed, reported an increased risk of seizures and side effects when:
1. They switched from one manufacturer’s formulation of an anti-epileptic drug to another…
2. They switched between different manufacturers’ versions of the same generic drug…
3. They switched from a generic to a brand-name drug…
4. Or they switched from a brand-name drug to a generic.
LikeLiked by 2 people
Comment by Phylis Feiner Johnson — July 24, 2020 @ 2:05 PM
Problem is what one country may have (the brand name medications we used to get) we can no longer get now for some reason. That makes thing VERY VERY DIFFICULT!!
LikeLiked by 1 person
Comment by Kathy S.B — July 29, 2020 @ 11:17 AM
I only remember once trying to replace the real thing with a generic. I don’t remember what drug it was but I know I never tried it again.
LikeLiked by 2 people
Comment by Ed Lugge — July 24, 2020 @ 1:13 PM
Oftentimes, the unknown “filler” is what doesn’t agree with you.
LikeLiked by 2 people
Comment by Phylis Feiner Johnson — July 24, 2020 @ 2:09 PM
THAT SEEMS TO BE EXACTLY MY PROBLEM!! Which has FINALLY been realized by all medical doctors at all levels, but only after I made sure to tell them and they received my file
LikeLiked by 1 person
Comment by Kathy S.B — July 29, 2020 @ 11:18 AM
I had problems with the generic brand of Keppra.
LikeLiked by 1 person
Comment by Corina M Perry — July 24, 2020 @ 1:51 PM
Corina, I agree with you that the generic version of Keppra had been my nightmare leading into hallucinating rage of total disorientation & lost mind, until I became aware that I’m wrecking the peace of my family everytime my rage threatened the stability of my family, forcing me to confront my Nuerologist to come up with better alternative.
Thanks God, going back to the brand name has made a whole lot differences more than staying with the cheaper generic prescription intended & pushed to make a whole lot of money for the insurance company & benefit corrupt doctors at the expense of uninformed gullible patients.
It has been excruciating journey to know the effects & find out the mistry behind the switch to generics, jeopardizing the state of mind.
Gerrie
LikeLiked by 2 people
Comment by BahreNegash Eritrea — July 27, 2020 @ 5:13 PM
THANK YOU GERRIE!! 😊🙏🏼🦅😇💕
LikeLiked by 1 person
Comment by Kathy S.B — July 29, 2020 @ 11:19 AM
After my incident with toperimate and knowing from some very close people about KEPPRA not only would my family say “NO!!!!!!!”, but so did I!! It took me 42 years to FINALLY MELLOW OUT I am NOT ABOUT TO TAKE ANY CHANCES!!!!!!!
LikeLiked by 1 person
Comment by Kathy S.B — July 29, 2020 @ 11:21 AM
You’re very welcome, Kathy.
It just impossible to believe that the “medicines” that were meant to cure our medical hardships can turn out to be more fatal than the medical hardships we’re trying to live with.
Thanks to generic Keppra, some of us had learned the hard way that some prescriptions are NOT made to remedy our medical hardships. a bitter reality to swallow.
Gerrie
LikeLiked by 2 people
Comment by BahreNegash Eritrea — July 29, 2020 @ 3:17 PM
But you were ok with the name-brand of Keppra Corina?
LikeLike
Comment by Phylis Feiner Johnson — July 24, 2020 @ 2:10 PM
Research I have done on this issue stated that the active ingredients or their effect could vary as much as 20% more or 20% less than the name-brand med, a gamble I’ve have never chosen to try.
LikeLiked by 3 people
Comment by Andy — July 24, 2020 @ 2:36 PM
And when you have that 20% unknown filler, it really is a gamble, as you say.
LikeLiked by 2 people
Comment by Phylis Feiner Johnson — July 24, 2020 @ 3:26 PM
Only the brand version of Keppra doesn’t cause me heightened side effects. Can’t tolerate generic version!
LikeLiked by 2 people
Comment by Lisa — July 24, 2020 @ 3:10 PM
Question for epilepsy advocates: Shouldn’t pharmacists be required to tell a patient who is taking an ongoing script when the manufacturer for said prescription has changed for the current refill? From a patient’s POV, It’s only fair warning!
LikeLiked by 3 people
Comment by Lisa — July 24, 2020 @ 3:16 PM
Yes. There’s also a “No Substitutions” form you can fill out and have signed by your doc.
Prevent Medication Changes… https://epilepsytalk.com/2011/09/14/prevent-medication-changes/
But, it’s easier just to have “No Substitutions” on your original script from the doctor.
LikeLiked by 2 people
Comment by Phylis Feiner Johnson — July 24, 2020 @ 3:21 PM
ABSOLUTELY YES!!!!!!! AS WELL AS THE DOCTORS!!
LikeLiked by 1 person
Comment by Kathy S.B — July 29, 2020 @ 11:22 AM
If I had been warned prior to ever changing any medications I would have told the pharmacist ASAP!!!!!!! But it already is in my file with the pharmacy and I was the one who had to backtrack to catch it MYSELF FIRST!! AND THEN I TOLD THE PHARMACIST AND MY DOCTOR!!!!!!! Even they seen it in the files AFTER THE FACT!!
LikeLiked by 1 person
Comment by Kathy S.B — August 10, 2020 @ 10:36 PM
How disgusting of these manufacturers. Shame on all of them, and all who profit off of people’s illnesses and desperation to feel better.
LikeLiked by 2 people
Comment by Hetty Eliot — July 24, 2020 @ 8:33 PM
I also wonder if many of us pile up add-on drugs because generics aren’t working well enough.
LikeLiked by 2 people
Comment by Hetty Eliot — July 24, 2020 @ 11:24 PM
That’s a wonderful question. One to ask BIG Pharma!
LikeLiked by 2 people
Comment by Phylis Feiner Johnson — July 25, 2020 @ 9:19 AM
Please ask BIG PHARMA and please let us know what they tell you (if they tell you anything at all). Thank you
LikeLiked by 2 people
Comment by Kathy S.B — July 29, 2020 @ 11:23 AM
Defiantly a difference. If you start out on brand and change to generic the compound ingredients are required to be the same. Even the dyes (or color) can make a difference.
LikeLiked by 2 people
Comment by betdam — July 26, 2020 @ 11:57 AM
For a generic, only 80% of the original compound drug is present. The other 20% is unknown “filler”
LikeLiked by 1 person
Comment by Phylis Feiner Johnson — July 26, 2020 @ 12:06 PM
I had a few instances of this. I moved after high school but stayed with the same chain. The generic Tegretol they had was a different company. I noticed within a few days there was a problem. Family had to drive about 12 miles to get them at the previous pharmacy.
Dilantin was another for me. I had to be on brand name. Generic’s levels would decay faster, or not hold at levels brand name would.
I want to say the FDA standard is +/- 20% with generics compared to brand name drug.
So YES if you notice issues when manufacturer is changed talk to your doctor, but more importantly pharmacy and see if they can obtain the previous or another manufacturer of your medication.
LikeLiked by 2 people
Comment by Travis — July 27, 2020 @ 10:54 AM
As you said, I think consistency is key.
LikeLiked by 1 person
Comment by Phylis Feiner Johnson — July 27, 2020 @ 10:57 AM
Me too!! But I do have to have to pay the difference out of pocket myself here in canada
LikeLiked by 1 person
Comment by Kathy S.B — July 29, 2020 @ 11:25 AM
Throughout my decades-long use of many different antiseizure meds and due to various financial situations, I’ve been on both generic and brand name meds. Sure, the generics are known to contain additives, etc. But believe me, they ALL have had horrible side-effects, ok? Losing hair, forgetting names or hallucinating are not sane way to live lives.
LikeLiked by 1 person
Comment by skolly9 — July 29, 2020 @ 7:21 PM
Yes Skolly, There’s a whole lot of neurological, psychological, physical, emotional, social & financial price to pay for taking those chemical compounds “medicine”, made to “remedy” our medical difficulties.
Knowing all the side effects of the medicines, life becomes about living with the lesser evil or accepting your fate.
And for many of us, coping with the side effects of the medicines ends up being a better alternative than having to languish with uncontrolled seizures.
Gerrie
LikeLiked by 2 people
Comment by BahreNegash Eritrea — July 29, 2020 @ 10:04 PM
Granted but if it is already in your file for decades it should be known now! Because sometimes those negative effect of the different additives may cause more problems down the line.
LikeLiked by 1 person
Comment by Kathy S.B — August 10, 2020 @ 10:41 PM
Re: pharmacist substituting generic for Dr. prescribed drug. I experienced horrible seizures when my Lamictal was changed to the generic. Pharmacist did not advise. My neurologist (to put it professionally) had to vehemently debate with my insurance company as to why I needed the Brand name. The company didn’t want to pay for it. I recommend one takes the same path and have your doctor pursue the change for you. I was very fortunate. Keep your eyes on the bottle!
LikeLiked by 2 people
Comment by Roy A. — July 30, 2020 @ 11:31 AM
I always do better with generic and liquid forms than the brand pills/capsules. I get the rare and unlisted side effects more and faster with the brands. I currently take Briviact Oral Solution and Zonisamide Compound.
LikeLiked by 2 people
Comment by trekkie80sgirl — August 5, 2020 @ 10:14 PM
That’s really interesting. I didn’t even KNOW that epilepsy meds were available in liquid form. (Goes to show how much I know!) And that the generic forms are more user-friendly for you. That’s interesting, too.
LikeLiked by 2 people
Comment by Phylis Feiner Johnson — August 5, 2020 @ 10:19 PM
Yes they have shops that can turn your medication into a liquid type. I believe their called “hypothocary pharmacies”
LikeLiked by 1 person
Comment by Kathy S.B — August 10, 2020 @ 10:43 PM