Epilepsy Talk

28 New Epilepsy Medicines In Development | July 18, 2017

A newly-released report from Pharmaceutical Research and Manufacturers of America (PhRMA) has revealed that 28 new medications are in development to treat epilepsy and seizures.

But that’s just the tip of the iceberg.

These 28 new drugs are among nearly 420 new ground-breaking medicines in progress to treat neurological disorders.

Of the 28 epilepsy medicines listed in the report, seven are in or have completed phase one of development, eight are in or have completed phase two and, thirteen are in or have completed phase three.

The large number of drugs currently in clinical trials provides a measure of hope for patients whose epilepsy is not controlled with currently available medication.

In the future, this range of antiepileptic drugs will probably increase because of the use of new animal models, discovery of new basic mechanisms of epileptogenesis, acceleration of proof of principle studies in people, and development of new methods of drug delivery.

Other potential medicines – all in human clinical trials or under review by the Food and Drug Administration (FDA) – are diverse in scope.

They include:

62 for brain tumors – primary brain tumors are diagnosed each year in nearly 70,000 Americans…
82 medicines for Alzheimer’s disease, which afflicts more than 5 million Americans…
82 for pain – aiding adults who experience chronic pain, approximately 100 million Americans…
38 for multiple sclerosis, which afflicts an estimated 500,000 Americans…
27 for Parkinson’s Disease, affecting as many as 1.5 million Americans…
25 for headache, a condition that affects about 28 million Americans…

“Collaboration among all partners in the medical innovation ecosystem – including patients – is critical to help advance scientific understanding of some of the most complicated neurological disorders,” added PhRMA President and CEO John J. Castellani.

“Even with all the advancements made to date — and the hope provided in the pipeline — we have much to learn about how the human brain functions.

“Together, we can make it happen.”

NOTE: The BRAIN Initiative

The BRAIN Initiative aims to accelerate the development and application of new technologies to help researchers understand the inter-workings of the brain, leading to new ways to treat and maybe one day prevent or cure diseases, such as epilepsy Alzheimer’s and traumatic brain injury.

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Resources:

http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(06)70627-5/abstract

http://phrma.org/press-release/innovative-medicines-in-development-for-neurological-disorders

http://phrma.org/meds-in-development/neurological-disorders#sthash.KafmN21P.dpuf

https://www.scribd.com/document/207657018/Medicines-in-Development-Neurological-Disorders-2013

Posted in Epilepsy, Medication Issues, News, Research
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21 Comments »

  1. I recently came across this article, which explains that scientists had found a new molecule which may help with neurological conditions, but I wasn’t expecting such a long list 🙂
    – http://www.fiercebiotech.com/research/new-protein-could-unravel-causes-epilepsy-other-neurological-disorders

    Like

    Comment by Liz Caldwell — July 18, 2017 @ 11:30 AM

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  2. I am all for the studies, & research for new AED’s and to make them WITHOUT all of the other fillers, aka chemicals, dyes, metals, preservatives and additives, that weaken seizure thresholds & cause seizures. FDA can start by banning all MAGNESIUM STEARATE as I know for most people if not everyone, it will make your digestive system work very slow or stop. My mother knows this as well as I do, when her BP drugs are saturated with Magnesium Stearates,and FIBER only adds to the problem with or without water added. Good laxatives are always getting used here, or else because of MAGNESIUM STEARATE. Less seizures were the result when DILANTIN was out of my life, back in the summer of 1986. Still Lamictal has this in it, but when only 100 MGS is taken daily, compared to 600 MGS of Dialntin & Meberal combined, there is clearly evidence about WHAT & HOW ”’magnesium stearate, effects ALL the digestive & brain health”’.

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    Comment by C D — July 18, 2017 @ 11:36 AM

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    • Point well taken.

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      Comment by Phylis Feiner Johnson — July 18, 2017 @ 12:14 PM

      Reply

    • More people are allergic to Magnesium Sterate and/or Cornstarch, the fillers of most pills. I am allergic to both. I only found out I was allergic to some inactive ingredients in the pills I was on this past year. There’s also many food dyes, etc. that people are sensitive to, yet may not know it. I certainly didn’t for a long time and I have had Epilepsy since I was 8 months old! I switched my Levetiracetam to syrup and Topiramate to compound because of the allergies.

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      Comment by trekkie80sgirl — July 19, 2017 @ 11:04 AM

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  3. In the post yesterday it mentions no more funding for epilepsy and reduced funding in relation to other neurological conditions so wondering how there are new meds in the pipeline as this is either funded via drug companies or government?

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    Comment by Jules — July 18, 2017 @ 4:38 PM

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  4. So many meds side effects have given me problems. I think Doctors look at the patients as their ‘guneia pigs’ and keep giving all the new drugs they really don’t know about yet. Think some of the medications give
    me worse problems than epilepsy

    Karen

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    Comment by Karen — July 18, 2017 @ 10:35 PM

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  5. My husband is 80 years and has been suffering from PD for the past 15 years. Lately he started hallucinating and I didn’t know how to handle the situation. He cannot sleep and tried to find and catch the imaginary people who he thinks are real. he was taken Entacapone with Levodopa, Carbidopa, and Pramipexole and started physical therapy to strengthen muscles. nothing was really working to help his condition.I took him off the Siferol (with the doctor’s knowledge) and started him on parkinson’s herbal formula i ordered from Health Herbal Clinic, his symptoms totally declined over a 5 weeks use of the Parkinsons disease natural herbal formula.i read reviews from other previous patients who used the herbal formula, my husband is now active, he can now go about daily exercise!! his symptoms so much reduced that now I hardly notice them.Visit there website www. healthherbalclinicc. weebly. com or email Info@ healthherbalclinic. net

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    Comment by Janice Tollis (@TollisJanice) — July 19, 2017 @ 6:53 AM

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  6. Reblogged this on catsissie.

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    Comment by catsissie — July 19, 2017 @ 8:26 PM

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  7. All good comments. I re-read #3, as it is so true. It is like epileptics are being ‘shoved aside’- to ‘heck’ with it, any other disorder is more important……………yeah. Let’s get with more research for epileptics. You would think everything else has had enough studies.made about it.

    Guess medical profession doesn’t give a ‘*’ about anything other than ‘stuffing’ people with meds
    they need to know more about before prescribing. I feel like a turkey stuffed with poison……………..

    Like

    Comment by Karen — August 10, 2017 @ 11:58 AM

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  8. Thank you so much for sharing. This was a great read. I started my blog a little over a month ago and it has been a wonderful experience. I have been able to connect with so many great people. I look forward to reading more of your posts. Take care!!

    Liked by 1 person

    Comment by alyssabowman — August 24, 2017 @ 8:55 PM

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  9. I respect the increase in meds and hope something works, but I am one that deals with uncontrollable seizures on any meds. I need a fix, not another med to try. Why are we not looking more for a cure? The money is in our government, studies can be done, and a cure would save life.

    Liked by 1 person

    Comment by Verka — September 16, 2017 @ 12:49 PM

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  10. Am a male aged 60 and diagnosed with Parkinson”s at 59. I had some symptoms for a few years before diagnosis; stiff achy right arm and ankle, right hand tremor when typing, tiredness, body shivers, falls due to tripping. I was always active, bicycle riding to/from work daily and putting in 2 to 3,000 miles on my bicycle per year. i was on Mysoline 250mg in 3 doses for the essential tremor. Madopar 200mgfour times a day. Sifrol 1mg three times a day, I started on Health Herbal Clinic Parkinsons Disease Herbal formula treatment in November 2016, i read alot of positive reviews on their success rate treating Parkinsons disease through their PD Herbal formula and i immediately started on the treatment. Just 8 weeks into the Herbal formula treatment I had great improvements, my hand tremors seized. I am unbelievably back on my feet again, visit Health Herbal Clinic official websiteMy have reduced my symptoms have so much reduced that now I hardly notice them.

    Like

    Comment by Edmund Criss — November 20, 2017 @ 1:01 AM

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    About the author

    Phylis Feiner Johnson

    Phylis Feiner Johnson

    I've been a professional copywriter for over 35 years. I also had epilepsy for decades. My mission is advocacy; to increase education, awareness and funding for epilepsy research. Together, we can make a huge difference. If not changing the world, at least helping each other, with wisdom, compassion and sharing.

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