For those new to Epilepsy Talk…
This page is a continuation of the first.
I found myself trying to reply to Doug’s query.
An hour later, satisfied with the research and reply, my answer wouldn’t “post”.
After a little screaming and stomping, I realized that not only had I lost hours of work, but we had run out of space, too.
Time for page 2.
Here’s Doug’s original post that inspired the copy below it. Which sounds as if it came from space. Or at least, doesn’t relate to Keppra.
“Just got another bone density test, and the numbers look worse. It is very frustrating, given I take vitamin supplements and exercise like crazy. I was moved to keppra and away from dilantin because it was supposedly better for bones. what are we supposed to do?”
The Contribution of Heredity
“The etimology of osteoporosis is clearly multifactorial in nature. While many of the non-genetic factors contributing to the risk for the disorder have been widely investigated in recent decades, the search for genetic determinants is relatively new, albeit very intense.
From family histories, twin studies, and molecular genetics, it is quite evident now that some of the predisposition for osteoporosis can be inherited. Genetic control of osteoporosis is polygenic; the specific genes involved are beginning to be enumerated.
Both structural and regulatory genes have been implicated in the propensity toward osteoporosis. Variance or mutation in genes that control bone mass (and its mineral content) and/or bone turnover are obvious candidate genes. Estimation of the genetic component to the variance found in bone mineral density (BMD), for example, ranges from 60% to 90%.
We will look at four of the primary areas where researchers have begun to forge the link between genetics and osteoporosis.”
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